Born out of a summer study at New York University in 2015, the National Security Technology Accelerator concept was transformed into the MD5 program office at the height of the Defense Innovation Initiative under Secretary of Defense Ash Carter. Like their sister organizations, the Defense Innovation Unit, Experimental (DIUx), and the Strategic Capabilities Office (SCO), MD5 represents divergent thinking and executes non-traditional approaches to problem solving that increase the permeability between the public and private domains. Within the Department of Defense, MD5 group, there are several regional centers focused on developing innovation hubs in different regions of the United States– for example, New York, Austin, Boston, Silicon Valley, etc. MD5 would like the Capstone team to analyze what the regional hubs should do to engage with the local start-up community to help support innovation and start-ups within that region?